Correlating Spinal Cord Diffusion Tensor Imaging Metrics to Clinical Measures in Patients with Adrenomyeloneuropathy
نویسندگان
چکیده
A. Gifford, K. Zackowski, J. Wang, P. C. van Zijl, G. Raymond, and S. Smith Department of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD, United States, Motion Analysis Laboratory, Kennedy Krieger Institute, Baltimore, MD, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, Department of Radiology, Vanderbilt University, Nashville, TN
منابع مشابه
Quantitative MRI of the spinal cord and brain in adrenomyeloneuropathy: in vivo assessment of structural changes.
Adrenomyeloneuropathy is the late-onset form of X-linked adrenoleukodystrophy, and is considered the most frequent metabolic hereditary spastic paraplegia. In adrenomyeloneuropathy the spinal cord is the main site of pathology. Differently from quantitative magnetic resonance imaging of the brain, little is known about the feasibility and utility of advanced neuroimaging in quantifying the spin...
متن کاملQuantitative assessment of the cervical spinal cord damage in neuromyelitis optica using diffusion tensor imaging at 3 Tesla.
PURPOSE To investigate whether quantitative MRI measures of cervical spinal cord white matter (WM) using diffusion tensor imaging (DTI) in neuromyelitis optica (NMO) differed from controls and correlated with clinical disability. MATERIALS AND METHODS Ten referred patients and 12 healthy volunteers were imaged on a 3 Tesla scanner and patients were clinically assessed on the Expanded Disabili...
متن کاملRelationship between timed 25-foot walk and diffusion tensor imaging in multiple sclerosis
OBJECTIVE/BACKGROUND The majority of multiple sclerosis patients experience impaired walking ability, which impacts quality of life. Timed 25-foot walk is commonly used to gauge gait impairment but results can be broadly variable. Objective biological markers that correlate closely with patients' disability are needed. Diffusion tensor imaging, quantifying fiber tract integrity, might provide s...
متن کاملASIA scores correlate with DTI Metrics in Non-Hemorrhagic Traumatic C-Spine Injury
Introduction Conventional magnetic resonance imaging (MRI) is the best imaging modality to demonstrate ligamentous injury, hematoma, disk herniation, spinal cord edema and hemorrhage that occur following trauma. Quantitative and qualitative image parameters like lesion length, maximum spinal cord compression, spinal cord swelling and, presence of hemorrhage within the cord has been reported to ...
متن کاملRecovery after spinal cord relapse in multiple sclerosis is predicted by radial diffusivity
BACKGROUND The aim of this study was to determine whether the diffusion tensor-derived radial diffusivity and axial diffusivity, measured in the cortico-spinal tract in the cervical cord, predict clinical recovery after a cord relapse in patients with multiple sclerosis, and change over time. METHODS Fourteen patients were clinically assessed at the onset of a cervical cord relapse and after ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009